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doi: 10.1155/2014/147251

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Numerous signaling pathways, such as cyclooxygenase 2 (COX-2), mammalian target of rapamycin (mTOR), mitogen-activated protein kinase (MAPK) signaling, phosphoinositide 3 kinase (PI3K), and the GATA4/p62-mediated autophagy pathways result in the stimulation of NF-κB and/or C/EBPβ pathways, which in turn regulate the SASP secretome (81, 82)